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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001140361-10-020932.txt : 20100513
<SEC-HEADER>0001140361-10-020932.hdr.sgml : 20100513
<ACCEPTANCE-DATETIME>20100513150536
ACCESSION NUMBER:		0001140361-10-020932
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100513
DATE AS OF CHANGE:		20100513
EFFECTIVENESS DATE:		20100513

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SENSORS FOR MEDICINE & SCIENCE INC
		CENTRAL INDEX KEY:			0001032158
		IRS NUMBER:				522000730
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-43030
		FILM NUMBER:		10828071

	BUSINESS ADDRESS:	
		STREET 1:		20451 SENECA MEADOWS PARKWAY
		CITY:			GERMANTOWN
		STATE:			MD
		ZIP:			20876
		BUSINESS PHONE:		301-515-7260

	MAIL ADDRESS:	
		STREET 1:		20451 SENECA MEADOWS PARKWAY
		CITY:			GERMANTOWN
		STATE:			MD
		ZIP:			20876
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001032158</cik>
        <entityName>SENSORS FOR MEDICINE &amp; SCIENCE INC</entityName>
        <issuerAddress>
            <street1>20451 SENECA MEADOWS PARKWAY</street1>
            <city>GERMANTOWN</city>
            <stateOrCountry>MD</stateOrCountry>
            <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
            <zipCode>20876</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>301-515-7260</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marc</firstName>
                <middleName>R.</middleName>
                <lastName>Schneebaum</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sensors for Medicine &amp; Science Inc</street1>
                <street2>20451 Seneca Meadows Parkway</street2>
                <city>Germantown</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20876</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>M.</firstName>
                <middleName>James</middleName>
                <lastName>Barrett, Ph.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sensors for Medicine &amp; Science Inc</street1>
                <street2>20451 Seneca Meadows Parkway</street2>
                <city>Germantown</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20876</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>H.</middleName>
                <lastName>Cavanaugh, Ph.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sensors for Medicine &amp; Science Inc</street1>
                <street2>20451 Seneca Meadows Parkway</street2>
                <city>Germantown</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20876</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bradley</firstName>
                <middleName>G.</middleName>
                <lastName>Lorimier</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sensors for Medicine &amp; Science Inc</street1>
                <street2>20451 Seneca Meadows Parkway</street2>
                <city>Germantown</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20876</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Charles</firstName>
                <middleName>W.</middleName>
                <lastName>Newhall III</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sensors for Medicine &amp; Science Inc</street1>
                <street2>20451 Seneca Meadows Parkway</street2>
                <city>Germantown</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20876</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gerard</firstName>
                <lastName>Vaillant</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sensors for Medicine &amp; Science Inc</street1>
                <street2>20451 Seneca Meadows Parkway</street2>
                <city>Germantown</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20876</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Francis</firstName>
                <middleName>H.</middleName>
                <lastName>Zenie</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Sensors for Medicine &amp; Science Inc</street1>
                <street2>20451 Seneca Meadows Parkway</street2>
                <city>Germantown</city>
                <stateOrCountry>MD</stateOrCountry>
                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
                <zipCode>20876</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001123292-09-000497</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-05-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Series C Convertible Preferred Stock (&quot;Series C Stock&quot;), convertible into common stock; options to purchase additional Series C Stock</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>30000000</totalOfferingAmount>
            <totalAmountSold>10000000</totalAmountSold>
            <totalRemaining>20000000</totalRemaining>
            <clarificationOfResponse>Up to 7,500,000 shares of Series C Stock at purchase price of $4.00 per share</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>SENSORS FOR MEDICINE &amp; SCIENCE INC</issuerName>
                <signatureName>x</signatureName>
                <nameOfSigner>Marc R. Schneebaum</nameOfSigner>
                <signatureTitle>President, CEO and Secretary</signatureTitle>
                <signatureDate>2010-05-12</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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