-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KZpSAphW62jrEP8gEcY0h4yC6N6tM8XaOQsire+Z1YN61j2t+LMgzyGXr4cGA0Fv
 vT8kHRB+NpBXumEuXtiIvQ==

<SEC-DOCUMENT>0001017163-11-000003.txt : 20110330
<SEC-HEADER>0001017163-11-000003.hdr.sgml : 20110330
<ACCEPTANCE-DATETIME>20110330165206
ACCESSION NUMBER:		0001017163-11-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20110330
DATE AS OF CHANGE:		20110330
EFFECTIVENESS DATE:		20110330

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SYNAGEVA BIOPHARMA CORP.
		CENTRAL INDEX KEY:			0001017163
		IRS NUMBER:				943244869
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-157597
		FILM NUMBER:		11722688

	BUSINESS ADDRESS:	
		STREET 1:		60 HICKORY DR.
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451
		BUSINESS PHONE:		7818901111

	MAIL ADDRESS:	
		STREET 1:		60 HICKORY DR.
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02451

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SYNAGEVA BIOPHARMA CORP
		DATE OF NAME CHANGE:	20090205

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AVIGENICS INC
		DATE OF NAME CHANGE:	19960619
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001017163</cik>
        <entityName>SYNAGEVA BIOPHARMA CORP.</entityName>
        <issuerAddress>
            <street1>128 SPRING STREET, SUITE 520</street1>
            <city>LEXINGTON</city>
            <stateOrCountry>MA</stateOrCountry>
            <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
            <zipCode>02421</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>781-357-9900</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>SYNAGEVA BIOPHARMA CORP</previousName>
            <previousName>AVIGENICS INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SANJ</firstName>
                <middleName>K.</middleName>
                <lastName>PATEL</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>THOMAS</firstName>
                <middleName>R.</middleName>
                <lastName>MALLEY</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>FELIX</firstName>
                <middleName>J.</middleName>
                <lastName>BAKER</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>SRINI</firstName>
                <lastName>AKKARAJU</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>MARK</firstName>
                <lastName>GOLDBERG</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>STEPHEN</firstName>
                <middleName>R.</middleName>
                <lastName>BIGGAR</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ROBYN</firstName>
                <lastName>SAMUELS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JAMES</firstName>
                <middleName>L.L.</middleName>
                <lastName>TULLIS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>C/O SYNAGEVA BIOPHARMA CORP.</street1>
                <street2>128 SPRING STREET, SUITE 520</street2>
                <city>LEXINGTON</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02421</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2011-03-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>25000000</totalOfferingAmount>
            <totalAmountSold>12500000</totalAmountSold>
            <totalRemaining>12500000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>22</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>SYNAGEVA BIOPHARMA CORP.</issuerName>
                <signatureName>SANJ K. PATEL</signatureName>
                <nameOfSigner>SANJ K. PATEL</nameOfSigner>
                <signatureTitle>PRESIDENT AND CHIEF EXECUTIVE OFFICER</signatureTitle>
                <signatureDate>2011-03-30</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----