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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 h3OzpPyGyBCbdOn/pVTXIQ==

<SEC-DOCUMENT>0001003226-09-000011.txt : 20090715
<SEC-HEADER>0001003226-09-000011.hdr.sgml : 20090715
<ACCEPTANCE-DATETIME>20090715133938
ACCESSION NUMBER:		0001003226-09-000011
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090715
DATE AS OF CHANGE:		20090715
EFFECTIVENESS DATE:		20090715

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TRI-ISTHMUS GROUP, INC.
		CENTRAL INDEX KEY:			0001003226
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-GENERAL MEDICAL & SURGICAL HOSPITALS, NEC [8062]
		IRS NUMBER:				770557617
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-52156
		FILM NUMBER:		09945555

	BUSINESS ADDRESS:	
		STREET 1:		9663 SANTA MONICA BLVD
		STREET 2:		SUITE 959
		CITY:			BEVERLY HILLS
		STATE:			CA
		ZIP:			90210-4303
		BUSINESS PHONE:		310-860-2501

	MAIL ADDRESS:	
		STREET 1:		9663 SANTA MONICA BLVD
		STREET 2:		SUITE 959
		CITY:			BEVERLY HILLS
		STATE:			CA
		ZIP:			90210-4303

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	VSOURCE INC
		DATE OF NAME CHANGE:	20000106

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INTERACTIVE BUYERS NETWORK INTERNATIONAL LTD
		DATE OF NAME CHANGE:	19990621
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0401</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001003226</cik>
        <entityName>TRI-ISTHMUS GROUP, INC.</entityName>
        <issuerAddress>
            <street1>433 North Camden Drive</street1>
            <street2># 810</street2>
            <city>BEVERLY HILLS</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>90210</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>310-860-2501</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>VSOURCE INC</previousName>
            <previousName>INTERACTIVE BUYERS NETWORK INTERNATIONAL LTD</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName></middleName>
                <lastName>Hirschhorn</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>433 North Camden Drive</street1>
                <street2># 810</street2>
                <city>Beverly Hills</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>90210</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>N.</middleName>
                <lastName>Schwartz</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6 Duquesa</street1>
                <street2></street2>
                <city>Dana Point</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92629</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Todd</firstName>
                <middleName></middleName>
                <lastName>Parker</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>456 Montgomery Street</street1>
                <street2>11th Floor</street2>
                <city>San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94104</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richardson</firstName>
                <middleName>E.</middleName>
                <lastName>Sells</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>18 Audubon Pond</street1>
                <street2></street2>
                <city>Hilton Head</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29928</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Donald</firstName>
                <middleName>C.</middleName>
                <lastName>Parkerson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2352 Woodland Circle</street1>
                <street2></street2>
                <city>Birmingham</city>
                <stateOrCountry>AL</stateOrCountry>
                <zipCode>35242</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Hospitals and Physicians</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-05-21</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>105000</totalOfferingAmount>
            <totalAmountSold>105000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>2</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>TRI-ISTHMUS GROUP, INC.</issuerName>
                <signatureName>Donald C. Parkerson</signatureName>
                <nameOfSigner>Donald C. Parkerson</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-07-15</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----